National Journal of Community Medicine

Original Article

Year: 2017 | Volume: 8 | Issue: 3 | Page No: 148-152

Discriminant Analysis of Rheumatoid Factor, Anti-Cyclic Citrullinated Peptide, and C-Reactive Protein for Rheumatoid Arthritis Patients

Author: Ausaf Ahmad, T.B. Singh, Usha, Navin Kumar



"Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint swelling, joint tenderness, and de-struction of synovial joints, leading to severe disability and premature mortality with uncertain aetiology by signi?cant morbidity and mortality. Prevalence of approximately 0.75% in India. About 40% diseased become work disabled within 5 years from onset of symptoms. Objectives: The study was conducted to determine the most parsimonious way to distinguish between groups and to test the theo-ry by which cases are classi?ed as predicted. Method: The study is based on 290 clinically suspected RA patients. Cross-sectional study design was used. Clinically suspected cases were referred by different OPD’s of Sir Sunderlal Hospital for screening. Result: RF, AntiCCP and CRP diagnosed RA 21.3%, 21.7% and 33.1% respectively as positive . 277/290 (92.1%) of respondents were classi?ed correctly into ‘RA’ or ‘non-RA’ groups. Non-RA were classi?ed with better accuracy (98.8%) than RA (58.3%). Interpretation & Conclusion: Early diagnosis of these high risk suspects will help in preventing from foremost disability. The quality of life may be approved of infected subjects by providing timely diagnosis and treatments and balanced nutritional and social supports. "

Keywords: Rheumatoid arthritis, discriminant analysis, Cross-sectional, classification