Abstract
Original Article
Year: 2011 | Volume: 2 | Issue: 2 | Page No: 225-228
Total antioxidant Status and Lipid Peroxides in Patients with Pulmonary Tuberculosis
Author: Deepak Parchwani, S. P. Singh, Digisha Patel
Affiliation:
Abstract:
Free radicals are potentially damaging to tissues, producing irreversible damage to biomolecules such
as enzymes, proteins and membrane lipids. The current study was conducted to assess the
concentration of malionaldehyde(MDA) as a marker of lipid peroxidation and total antioxidant
status(TAS) in patients with active pulmonary tuberculosis and to examine the influence of
chemotherapy on these parameters. 45 patients were enrolled into the study. 20(Group I) had only
small radiographical changes and were sputum negative. The remainder 25(Group II) had advanced
pulmonary tuberculosis and were sputum smear positive. The control group consisted of 20 clinically
healthy individuals. In group I & II blood samples were collected for examination before and after 6
months of treatment period with tuberculostatic drugs. Data was analyzed by SPSS software. In
patients with pulmonary tuberculosis, both before and after chemotherapy , serum MDA
concentration was significantly higher and the content of TAS was significantly lowered in
comparison to the control group, though in the course of treatment MDA concentration decreased
significantly while the concentration of TAS were stable. These results suggest that increased
circulating levels of free radical activity along with decreased TAS are found in active pulmonary
tuberculosis and hence may play a role in the resultant fibrosis. It also reinforces the belief that
inclusion of antioxidants to the therapy may prove to be useful.
Keywords: Antioxidant, Lipid Peroxides, Pulmonary Tuberculosis
DOI:
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